![]() These epidemiological surveys have generated useful hypotheses and spawned secondary research seeking mechanistic explanations for the emerging patterns. No studies have contributed more to an understanding of the causation and aetiology of multiple sclerosis than those charting its global distribution. ![]() In this situation, it is essential to know that claims for reported differences in morbidity statistics are reliable. The commonest reason for carrying out an epidemiological survey is to use temporal and geographical gradients, and variations in risk depending on location over defined periods, to generate hypotheses for causation of the disease. This is particularly true when comparisons have been made between the frequency of multiple sclerosis in different places, or when one area has been surveyed repeatedly over time. ![]() Few have proved definitive and methodological factors have often limited the extent to which useful conclusions can be drawn. In practice, the aims of these surveys have varied. Listing individuals in whom the diagnosis has already been made, or identifying those with one particular feature of the disease, is not a difficult exercise, only requiring clinical resources and limited epidemiological expertise. Morbidity statistics for multiple sclerosis have been surveyed in many places, on many occasions and for many reasons. ![]() THE RATIONALE FOR EPIDEMIOLOGICAL STUDIES IN MULTIPLE SCLEROSIS ![]()
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